Sperm DNA fragmentation is one of the potential causes of male infertility, even when standard semen parameters appear normal. This test measures the percentage of sperm cells with damaged DNA. Such damage may hinder fertilization, affect embryo development, or result in miscarriage.

If you and your partner are experiencing difficulties conceiving, and semen analysis shows normal concentration, motility, and morphology, consider discussing a sperm DNA fragmentation test with your doctor. A high level of DNA fragmentation may be an underlying cause of infertility.

When Is the Test Recommended?

• Unexplained infertility
• Oligoasthenoteratozoospermia (OAT) or teratozoospermia
• Recurrent miscarriage
• Repeated IVF/ICSI failures
• Men over 35 years old
• Chronic inflammation of the male reproductive system
• Varicocele
• Poor embryo quality in ART programs
• Low fertilization rates in IVF
• Fever within the past 3 months
• Before sperm cryopreservation

How to Prepare for the Test:

• Abstain from sexual activity (including masturbation) for 3–5 days
• Avoid alcohol for at least 7 days before the test
• Avoid saunas, hot baths, and overheating for at least 7 days

The lower the level of sperm DNA fragmentation, the higher your chances of becoming happy parents.

Consult your physician for personalized advice.